Heart & Metabolic Health

Insulin Resistance

Insulin resistance occurs when muscle, fat, and liver cells respond less effectively to insulin.

Also known as: reduced insulin sensitivity

Updated November 13, 2026 · Patient education

Understanding Insulin Resistance

Insulin helps regulate glucose in the blood. When cells respond less well, the pancreas may produce more insulin to compensate. Blood glucose can rise if compensation is no longer sufficient.

How it is assessed or used in care

Insulin resistance can be associated with prediabetes and type 2 diabetes, but the terms do not mean the same thing. It often has no symptoms. Clinicians usually assess related risks and glucose results rather than diagnosing it from a symptom or routine insulin measurement alone.

What to discuss with your clinician

Ask how your glucose, blood pressure, lipid levels, and family history fit together. Physical activity, nutrition, and weight management when appropriate can be part of care. Your clinician can explain whether medication or additional testing is needed.

Medical references

  1. Insulin Resistance & Prediabetes - NIDDK

Sources accessed November 13, 2026.

This information is for general education, not a diagnosis or an individualized treatment plan. Discuss symptoms, test results, and treatment decisions with a qualified clinician. For a medical emergency, call 911.